CK2-IN-15
CK2-IN-15 (Compound Biv5) is a selective and potent bivalent protein kinase CK2 inhibitor with an IC50 value of 51 pM. CK2-IN-15 significantly reduces the replication of SARS-CoV-2 in HEK-ACE2-TMPRSS2 and Vero cells, and also reduces viral replication in an ex vivo model of human nasal epithelial cells. CK2-IN-15 is promising for research of β-coronavirus infection-related diseases[1].
Product Specifications
UNSPSC
12352005
Target
Casein Kinase; SARS-CoV
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Stem Cell/Wnt
Field of Research
Infection
Smiles
O=C(C1=CC=C2C(N=C(NCCCCCCCCNCC3=CC=C(C4=CC=CC=C4)C(Cl)=C3)C5=C2C=NC=C5)=C1)O
Molecular Formula
C34H35ClN4O2
Molecular Weight
567.12
References & Citations
[1]Grenier D, et al. Picomolar bivalent inhibitors of protein kinase CK2 active against β-coronavirus replication. Eur J Med Chem. 2025 May 29;296:117826.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK2
Curated Selection
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