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PAD-IN-3

PAD-IN-3 (Compound 16) is a potent dual peptidyl arginine deiminases 4 (PAD4) and PAD1 inhibitor with IC50 values of 0.204 μM and 0.273 μM, respectively. PAD-IN-3 is promising for research of citrullination-associated disorders such as cancer and autoimmune diseases[1].

Product Specifications

UNSPSC

12352005

Target

Protein Arginine Deiminase

Related Pathways

Epigenetics

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Smiles

OC1=CC2=C(C=C1)C=CC(C(N[C@@H](CCCNC(CCl)=N)C(NCC3=CC=CC=C3)=O)=O)=C2

Molecular Formula

C25H27ClN4O3

Molecular Weight

466.96

References & Citations

[1]Jia Y, et al. Discovery of highly potent naphthalene/quinoline-based PAD inhibitors: Structure-activity relationship, selectivity, and cytotoxicity. Eur J Med Chem. 2025 May 29;296:117830.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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