BRD4-IN-10
BRD4-IN-10 (Compound 31) is a selective BRD4 inhibitor with an IC50 of 13.5 nM. BRD4-IN-10 can exert anti-inflammatory and anti-fibrotic effects. BRD4-IN-10 also has good metabolic stability, pharmacokinetic properties and safety. BRD4-IN-10 can be used in the research of renal fibrosis diseases[1].
Product Specifications
CAS Number
[3051852-76-4]
UNSPSC
12352005
Target
Epigenetic Reader Domain
Related Pathways
Epigenetics
Field of Research
Inflammation/Immunology
Smiles
O=C1NC(C2(CCN(C3=NC(NC4=CC(N(C(C)C)[C@H](C)C(N5C)=O)=C5C=C4)=NC=C3)CC2)N1)=O
Molecular Formula
C24H30N8O3
Molecular Weight
478.55
References & Citations
[1]Huang J, et al. Development of a potent BET inhibitor for the treatment of renal fibrosis. Eur J Med Chem. 2025 Oct 5;295:117822.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
Curated Selection
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