Hsp90-Cdc37-IN-4
Hsp90-Cdc37-IN-4, a Celastrol derivative, inhibits the Hsp90-Cdc37 protein-protein interaction (PPI). Hsp90-Cdc37-IN-4 selectively inhibits casein kinase 2 (CK2), reducing phosphorylation of its substrate Cdc37 at Serine 13. Hsp90-Cdc37-IN-4 induces G0/G1 cell cycle arrest and triggers apoptosis via the mitochondrial pathway. Hsp90-Cdc37-IN-4 demonstrates potent anti-breast cancer activity[1].
Product Specifications
CAS Number
2758818-41-4
UNSPSC
12352005
Target
Apoptosis; Casein Kinase; HSP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1C(O)=C(C)C2=CC=C([C@](CC[C@]3(C)[C@@]4([H])C[C@](C)(C(NCCCOC(/C=C/C5=NC=CC=C5)=O)=O)CC3)(C)[C@@]4(C)CC6)[C@]6(C)C2=C1
Molecular Formula
C40H50N2O5
Molecular Weight
638.84
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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