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TRPV1 agonist-1

TRPV1 agonist-1 (Compound 13) is an orally active non-irritating TRPV1 agonist with EC50 values of 4.5 and 0.57 nM for human and rat. TRPV1 agonist-1 can improve swallowing function in rats. TRPV1 agonist-1 can be used in the research of dysphagia[1].

Product Specifications

CAS Number

2763372-26-3

UNSPSC

12352005

Target

TRP Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Others

Smiles

COC(C=C1CC(NC2=CC=CC([C@H]3CC[C@H](CC3)OC(C4CCCCC4)=O)=C2)=O)=C(C=C1)O

Molecular Formula

C28H35NO5

Molecular Weight

465.58

References & Citations

[1]Kitano H, et al. Discovery of nonpungent Transient Receptor Potential Vanilloid (TRPV1) agonist antedrugs for treatment of dysphagia. Bioorg Med Chem Lett. 2025 Sep 1;125-126:130287.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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