ELQ-453
ELQ-453 is an inhibitor targeting the Qo site of the Plasmodium falciparum cytochrome bc1 complex (CytB) with an IC50 value of 0.57 nM. ELQ-453 blocks the mitochondrial function of the parasite, and suppresses Plasmodium infection in mosquitoes. ELQ-453 is promising for research of malaria[1].
Product Specifications
UNSPSC
12352005
Target
Cytochrome P450; Parasite
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
FC1=C2C(N=C(C)C(CCCCCCC)=C2OCOC(OCC)=O)=CC(F)=C1
Molecular Formula
C21H27F2NO4
Molecular Weight
395.44
References & Citations
[1]Probst AS, et al. In vivo screen of Plasmodium targets for mosquito-based malaria control. Nature. 2025 May 21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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