GPER/Bcl-2-IN-1
GPER/Bcl-2-IN-1 is a GPER/Bcl-2 inhibitor. GPER/Bcl-2-IN-1 can inhibit the proliferation and neurospheres formation of glioblastoma cells. GPER/Bcl-2-IN-1 can be used for the study of glioblastoma multiforme (GBM) [1].
Product Specifications
UNSPSC
12352005
Target
Bcl-2 Family; Estrogen Receptor/ERR
Related Pathways
Apoptosis; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Smiles
ClC1=CC=C(S(NC(C2=CC=C3C([C@H](C=CC4)[C@H]4[C@H](C5=C(Br)C=C(OCO6)C6=C5)N3)=C2)=O)(=O)=O)C=C1
Molecular Formula
C26H20BrClN2O5S
Molecular Weight
587.87
References & Citations
[1]Méndez-Luna D et, al. Preclinical approach of two novel tetrahydroquinoline derivatives targeting GPER and Bcl-2 for anti-glioblastoma therapy. Sci Rep. 2025 May 21;15 (1) :17710.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2
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