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PX5–9

PX5-9 is an orally active prodrug that can upregulate brain-derived neurotrophic factor (BDNF) . PX5–9 exerts neuroprotective effects by elevating intracellular BDNF levels. PX5-9 can be used for the research of neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease) and depression, which are associated with reduced BDNF levels[1].

Product Specifications

UNSPSC

12352005

Target

Drug Metabolite

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

COC1=C(OC2CCCC2)C=CC(/C=C/C(NC3=CC=C([N+](C)([O-])C)C=C3)=O)=C1

Molecular Formula

C23H28N2O4

Molecular Weight

396.48

References & Citations

[1]Zhang Z, et al. Design and characterization of N-oxide cinnamanilide derivative PX5-9: Improved solubility and BDNF upregulation. Bioorg Med Chem Lett. 2025 Sep 1;125-126:130266.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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