Survivin-IN-1

Survivin-IN-1 (Compound II₃) is a potent Survivin (a member of the Inhibitor of Apoptosis Protein family) inhibitor with an IC50 value of 8.1 μM against human lung cancer A549 cells and 9.0 μM against breast cancer MCF-7 cells. Survivin-IN-1 reduces Survivin protein levels and induces tumor cell apoptosis. Survivin-IN-1 is promising for research of malignant tumors such as lung cancer and breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Survivin

Related Pathways

Apoptosis

Field of Research

Cancer

Smiles

O=C(N1CCN(C(NC2=CC=C(F)C=C2)=O)CC1)[C@@]34CC[C@@]5(C)[C@]6(C)CCC7[C@@](COC(C)=O)(C)[C@@H](OC(C)=O)[C@H](OC(C)=O)C[C@]7(C)C6CC=C5C3[C@@H](C)[C@H](C)CC4

Molecular Formula

C47H66FN3O8

Molecular Weight

820.04

References & Citations

[1]Wu H, et al. Design, synthesis, and activity evaluation of Asiatic acid derivatives as Survivin inhibitors. Bioorg Med Chem Lett. 2025 Sep 1;125-126:130288.