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CYP1A1-IN-1

CYP1A1-IN-1 (Compound 47) is a small-molecule cytochrome P4501A1 (CYP1A1) inhibitor. CYP1A1-IN-1 reduces the bacterial loads of methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii by enhancing macrophage phagocytosis. CYP1A1-IN-1 is promising for research of sepsis caused by multidrug-resistant (MDR) bacteria[1].

Product Specifications

CAS Number

3065926-17-9

UNSPSC

12352005

Target

Bacterial; Cytochrome P450

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection; Cardiovascular Disease

Smiles

O=C1N(C2=CC=C(C=C2N1C)C(/C=C/C3=CC=CC=C3C#C)=O)C

Molecular Formula

C20H16N2O2

Molecular Weight

316.35

References & Citations

[1]Wang F, et al. Discovery of CYP1A1 Inhibitors for Host-Directed Therapy against Sepsis. J Med Chem. 2025 Jun 12;68 (11) :11606-11627.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CYP1

Frequently Asked Questions

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