Cholesterol 24-hydroxylase-IN-3

Cholesterol 24-hydroxylase-IN-3 is an orally active, selective, and blood-brain barrier-penetrant CH24H inhibitor (IC50 = 23 nM) belonging to 1,3-oxazole derivatives. Cholesterol 24-hydroxylase-IN-3 competitively inhibits CH24H enzyme activity by using the 1,3-oxazole nitrogen atom to coordinate the heme iron and the cyclopropyl group occupying the hydrophobic pocket. Cholesterol 24-hydroxylase-IN-3 can be used for research on epilepsy and other neurological diseases[1].

Product Specifications

CAS Number

[1630746-27-8]

UNSPSC

12352005

Target

Cytochrome P450

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

98.74

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(C1CC1)NC2=CC(C(F)(F)F)=CC(C3=CN=CO3)=N2

Molecular Formula

C13H10F3N3O2

Molecular Weight

297.23

References & Citations

[1]Zheng Yang, et al. Design, synthesis, and in vitro and in vivo anti-drug resistant cervical cancer activity of novel licochalcone A derivatives based on dual targeting of VEGFR-2/P-gp. Eur J Med Chem. 2025 May 28 163:108639.