Mrt-5702D
Mrt-5702D is a molecular glue degrader targeting cereblon (CRBN) . mrt-5702D forms a CRBN-MRT-5702D-G3BP2 ternary complex to activate the ubiquitin-proteasome system for G3BP2 degradation. mrt-5702D is promising for research of G3BP2-related cancers (e.g., breast cancer, lung cancer) and neurodegenerative diseases[1].
Product Specifications
UNSPSC
12352005
Target
Molecular Glues
Related Pathways
PROTAC
Field of Research
Cancer; Neurological Disease
Smiles
C[C@H]1C2=CC=CC=C2C[C@H](N1S(=O)(CC3=CC=CC=C3Cl)=O)C(NCC4=CC5=NC=C(N5C=C4)N6CCC(NC6=O)=O)=O
Molecular Formula
C30H29ClN6O5S
Molecular Weight
621.11
References & Citations
[1]Annunziato S, et al. Molecular surface mimicry enables CRBN to target G3BP2 for degradation[J]. bioRxiv, 2025: 2025.04. 30.651496.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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