BChE/AChE-IN-1

BChE/AChE-IN-1 (Compound 4m) is a potent dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 0.7 μM and 0.2 μM, respectively. BChE/AChE-IN-1 is promising for research of neurodegenerative diseases such as Alzheimer’s disease (AD) [1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE)

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C1CCCCN1C2=CC(F)=C(C=C2)N3C=C(N=N3)C4=CC=C(Cl)C=C4

Molecular Formula

C19H16ClFN4O

Molecular Weight

370.81

References & Citations

[1]Cavallaro V, et al. Dual cholinesterase inhibition by lactam-1,2,3-triazole hybrids: A click chemistry approach for drug discovery. Bioorg Chem. 2025 May 30;163:108643.