Anti-MRSA agent 28
Anti-MRSA agent 28 is an antibacterial agent against multidrug resistant (MDR) gram-positive strains with MICs of 0.06-0.125 μg/mL. Anti-MRSA agent 28 can target DNA polymerase IIIC to reduce the amount of genomic DNA with the IC50 of 3.80 μg/mL. Anti-MRSA agent 28 has good antibacterial activity and reduces inflammation. Anti-MRSA agent 28 can be used against gram-positive strains and infectious conditions[1].
Product Specifications
CAS Number
2222727-47-9
UNSPSC
12352005
Target
Bacterial; DNA/RNA Synthesis
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
COC1=C(C2=C(C3=C4C5=C(C6=C(OCO6)C=C5CC[N+]4=C2)C=C3)C=C1)OC(C7=CC(C)=NN7C)=O.[Cl-]
Molecular Formula
C27H22ClN3O5
Molecular Weight
503.93
References & Citations
[1]Fan T, et al. Evolution of 8-esterified cycloberberines as a novel class of antibacterial agents against MDR gram-positive strains by targeting DNA polymerase IIIC. Bioorg Chem. 2025 May 28;163:108640.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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