SHP2-IN-38
SHP2-IN-38 is a novel green-fluorescent SHP2 inhibitor with IC50 values of 2.89 μM (SHP2), 8.73 μM (SHP1), 11.08 μM (PTP1B), 33.07 μM (TCPTP) . SHP2-IN-38 blocks the SHP2-mediated ERK signaling pathway and inhibits MV4-11 cells proliferation in vitro with IC50 of 7.90 μM. SHP2-IN-38 has an excitation wavelength of 360 nm, with a maximum emission wavelength of 550 nm in DMSO and 540 nm in DMF. SHP2-IN-38 shows green fluorescence imaging in HeLa cells and zebrafish[1].
Product Specifications
UNSPSC
12352100
Target
ERK; Fluorescent Dye; SHP2
Related Pathways
MAPK/ERK Pathway; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
OC1=C(C(O)=O)C=C(C2=CN(N=C(/C=C/C3=CC=C(C)C=C3)S4)C4=N2)C=C1
Molecular Formula
C20H15N3O3S
Molecular Weight
377.42
References & Citations
[1]Zhang C, et al. Discovery of novel imidazo[2,1-b][1,3,4]thiadiazole analogs as fluorescent SHP2 inhibitors. Bioorg Chem. 2025 May 27;163:108635.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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