WZH-15-125
WZH-15-125 is a potent ALK inhibitor. WZH-15-125 can effectively overcome drug resistance, especially compound ALK mutations. WZH-15-125 has an IC50 of 101.7 nM for the highly refractory G1202R/L1196M mutation that is resistant to Lorlatinib (HY-12215) . WZH-15-125 can be used as a PROTAC target protein ligand to synthesize PROTAC WZH-17-002 (HY-174315) . WZH-15-125 can be used in the research of non-small cell lung cancer[1].
Product Specifications
CAS Number
[2845188-22-7]
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; Ligands for Target Protein for PROTAC
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
BrC1=CN=C(N=C1NC2=CC=C3OCCOC3=C2N(S(C)(=O)=O)C)NC4=C(OC)C=C(C(CC)=C4)N5CCC(CC5)N6CCN(CC6)C
Molecular Formula
C33H45BrN8O5S
Molecular Weight
745.73
References & Citations
[1]Gao F, et al. Discovery of an ALK degrader for lorlatinib-resistant compound mutations. Eur J Med Chem. 2025 Jun 2;296:117835.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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