Antibacterial agent 284

Antibacterial agent 284 (Compound 7) is an Antibacterial agent. Antibacterial agent 284 has a zinc-binding structure and potent inhibitory activity against Legionella pneumophila metalloprotease ProA (IC50: 0.96 μM) with zinc-binding structure. Antibacterial agent 284 significantly inactivates the cleavage of collagen IV and flagellin (ProA substrates) and reduces immune evasion from the TLR5-NF-κB pathway and PMN-mediated inflammation in human lung tissue explants. Antibacterial agent 284 is promising for Legionnaires' disease research[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; Collagen; Toll-like Receptor (TLR)

Related Pathways

Anti-infection; Cytoskeleton; Immunology/Inflammation

Field of Research

Infection; Inflammation/Immunology

Smiles

CC(CC(P(O)(O)=O)C(N[C@@H](C(C)C)C(NC1=CC=C(C(Cl)=C1)Cl)=O)=O)C

Molecular Formula

C17H25Cl2N2O5P

Molecular Weight

439.27

References & Citations

[1]Scheithauer L, et al. Innovative zinc-binding inhibitors of Legionella pneumophila ProA reduce collagen and flagellin degradation, TLR5 evasion, and human lung tissue inflammation. Eur J Med Chem. 2025 May 30;296:117832.