Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

NLRP3-IN-81

NLRP3-IN-81 (N102) is a BBB-penetrable inhibitor against NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM against cell pyroptosis induced by Nigericin. NLRP3-IN-81 potently inhibits NLRP3-dependent activation of caspase-1 and the release of IL-1β. NLRP3-IN-81 disturbs the interaction of NLRP3 with the adaptor protein ASC and inhibits ASC oligomerization. NLRP3-IN-81 can be used for pyroptosis-related diseases research, such as inflammatory bowel diseases and type 2 diabetes[1].

Product Specifications

CAS Number

2922814-85-3

UNSPSC

12352005

Target

Caspase; Interleukin Related; NOD-like Receptor (NLR) ; Pyroptosis

Related Pathways

Apoptosis; Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

O=S(C1=NN=C(C=C1)C2=C(C=C(C=C2)C(F)(F)F)O)(C3CCCC3)=O

Molecular Formula

C16H15F3N2O3S

Molecular Weight

372.36

References & Citations

[1]Nan J, et al. Discovery and structure-activity relationship studies of 3-pyridazinesulfonyl derivatives as a new class of inhibitors against NLRP3 inflammasome-dependent pyroptosis. Eur J Med Chem. 2025 May 29;296:117796.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Caspase 1; IL-1; NLRP3

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Stefin B (CSTB) Rabbit Polyclonal Antibody
AP06334PU-N 100 µg

Stefin B (CSTB) Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
3-Mercaptohexanol
TRC-M225270-10G 10 g

3-Mercaptohexanol

Sign In for Pricing
View Details
GRIK3 Human Gene Knockout Kit (CRISPR)
KN423571 1 Kit

GRIK3 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
6-Hydroxy-3,4-dihydro-1H-quinoline-2-one
TRC-H941423-1G 1 g

6-Hydroxy-3,4-dihydro-1H-quinoline-2-one

Sign In for Pricing
View Details
WAC-AS1 Human qPCR Primer Pair (XM_030012)
HP220744 200 Reactions

WAC-AS1 Human qPCR Primer Pair (XM_030012)

Sign In for Pricing
View Details
SC 514
SIH-475-50MG 50 mg

SC 514

Sign In for Pricing
View Details