NLRP3-IN-81
NLRP3-IN-81 (N102) is a BBB-penetrable inhibitor against NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM against cell pyroptosis induced by Nigericin (HY-127019) . NLRP3-IN-81 potently inhibits NLRP3-dependent activation of caspase-1 and the release of IL-1β. NLRP3-IN-81 disturbs the interaction of NLRP3 with the adaptor protein ASC and inhibits ASC oligomerization. NLRP3-IN-81 can be used for pyroptosis-related diseases research, such as inflammatory bowel diseases and type 2 diabetes[1].
Product Specifications
CAS Number
[2922814-85-3]
UNSPSC
12352005
Target
Caspase; Interleukin Related; NOD-like Receptor (NLR) ; Pyroptosis
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O=S(C1=NN=C(C=C1)C2=C(C=C(C=C2)C(F)(F)F)O)(C3CCCC3)=O
Molecular Formula
C16H15F3N2O3S
Molecular Weight
372.36
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 1; IL-1; NLRP3
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