ZSA-215

ZSA-215 is a potent and orally active STING agonist with an EC50 of 3.3 μM. ZSA-215 enhances STING signaling through promoting the phosphorylation of STING and interferon regulatory factor 3 (IRF3) and secretion of IFN-β. ZSA-215 inhibits tumor regression and long-term survival of mice in MC38 colon cancer model. ZSA-215 can be used to the study of colon cancerr[1].

Product Specifications

UNSPSC

12352005

Target

STING

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Smiles

COC1=C(C=C2C([Se]C(C(NC[C@H](C(O)=O)CC)=O)=C2F)=C1)OC

Molecular Formula

C16H18FNO5Se

Molecular Weight

402.28

References & Citations

[1]1. Zhao HY et al. Design of an Oral STING Agonist through Intramolecular Hydrogen Bond Ring Mimicking to Achieve Complete Tumor Regression. J Med Chem. 2025 Jun 12;68 (11) :11365-11385.