Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide

Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide is a drug-linker conjugate for ADC. Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide consists of a Triptolide (HY-32735) and a stable and cleavable linker (Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-Cl) (HY-174810) . Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide can be used for synthesis of antibody-drug conjugates (ADC) [1].

Product Specifications

UNSPSC

12352005

Target

Drug-Linker Conjugates for ADC

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

95.59

Smiles

O=C([C@@H]1CN(S(=O)(C=C)=O)CCN1S(=O)(C=C)=O)NCC(N=N2)=CN2CCOCCOCCOCCO[Si](O[C@@H]3[C@]4(O[C@H]4[C@@H]5O[C@@]56[C@]7(CCC8=C([C@@]7(C[C@@H]9O[C@]936)[H])COC8=O)C)C(C)C)(C(C)C)C(C)C

Molecular Formula

C46H70N6O15S2Si

Molecular Weight

1039.29

References & Citations

[1]Wang H, et al. Triptolide-based cleavable antibody-drug conjugates for pancreatic cancer. Eur J Med Chem. 2025 Oct 5;295:117798.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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