NNRT-IN-9
NNRT-IN-9 (Compound EG28) is a non-nucleoside reverse transcriptase (NNRT) inhibitor. NNRT-IN-9 has potent antiviral and anti-resistance activity against wild-type (WT) HIV-1 and various clinically relevant mutations (E138K and K103N + Y181C) with EC50s of 55, 67 and 3910 nM, respectively. NNRT-IN-9 can be used for acquired immune deficiency syndrome (AIDS) research[1].
Product Specifications
UNSPSC
12352005
Target
HIV; Reverse Transcriptase
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
N#CC1=CC(N2C(N(CC3=CC=CC=C32)CC4=NNC5=NC=CC=C45)=O)=CC=C1
Molecular Formula
C22H16N6O
Molecular Weight
380.40
References & Citations
[1]Goffin E, et al. Discovery and SAR exploration of novel nanomolar 3,4-dihydroquinazolin-2 (1H) -one non-nucleoside reverse transcriptase inhibitors. Eur J Med Chem. 2025 May 29;296:117818.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
Curated Selection
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