PIM-1/HDAC-IN-2
PIM-1/HDAC-IN-2 is a robust PIM/HDAC inhibitor (IC50 = 0.11 μM in MV4-11cells), which exerts a synergistic antiproliferative effect through a dual mechanism of inhibiting PIM1 kinase and selectively inhibiting HDAC6. PIM-1/HDAC-IN-2 induces cell apoptosis. PIM-1/HDAC-IN-2 remarkably induces the cleavage of PARP, thereby initiating the arrest of the cell cycle in G1 phase and a reduction in S phase. PIM-1/HDAC-IN-2 demonstrates significant anticancer efficacyin the MV4-11 xenograft model without notable toxicity[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; HDAC; PARP; Pim
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1N(C(NC2CCN(CC2)CC3=CC=C(C=C3)/C=C/C(NO)=O)=NC4=C1C=CC=C4C5=CC6=C(N5)[C@H](NC6=O)C)C7(C)CC7
Molecular Formula
C34H37N7O4
Molecular Weight
607.70
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9; PIM1
Frequently Asked Questions
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