Cholic acid-Glu
Cholic acid-Glu is a derivative of Cholic acid (HY-N0324) . The abundance of Cholic acid-Glu is increased in Crohn’s disease. Cholic acid-Glu increases PXR activation and significantly increases the expression of the downstream PXR target gene Cyp3a11 in small intestinal organoid tissue[1].
Product Specifications
CAS Number
[95051-21-1]
UNSPSC
12352005
Target
Pregnane X Receptor (PXR)
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(N[C@H](C(O)=O)CCC(O)=O)=O)([H])[C@@]3([H])[C@@](C[C@@H]1O)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C
Molecular Formula
C29H47NO7
Molecular Weight
521.69
References & Citations
[1]Gentry EC, et al. Reverse metabolomics for the discovery of chemical structures from humans. Nature. 2024 Feb;626 (7998) :419-426.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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