SIRT1-IN-6
SIRT1-IN-6 (Compound NP1) is a SIRT1 inhibitor (IC50: 9.7 μM) . SIRT1-IN-6 increases p53 acetylation. SIRT1-IN-6 can be used for research of prophylaxis and neurodegenerative diseases or cancer[1].
Product Specifications
CAS Number
1174387-32-6
UNSPSC
12352005
Target
MDM-2/p53; Sirtuin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Smiles
O=C1OC(CC(O)=O)C(C2=C(OC)C=C(C3=CC=C(O)C=C3)C(OC)=C2O)=C1
Molecular Formula
C20H18O8
Molecular Weight
386.35
References & Citations
[1]Sascha Sauer, et al. Foam cell specific Liver X Receptor (LXR) alpha agonist, SIRT1 inhibitors as well as p300 inhibitors as pharmaceutically active agentsPatent. EP2759295
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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