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SIRT1-IN-6

SIRT1-IN-6 (Compound NP1) is a SIRT1 inhibitor (IC50: 9.7 μM) . SIRT1-IN-6 increases p53 acetylation. SIRT1-IN-6 can be used for research of prophylaxis and neurodegenerative diseases or cancer[1].

Product Specifications

CAS Number

1174387-32-6

UNSPSC

12352005

Target

MDM-2/p53; Sirtuin

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Smiles

O=C1OC(CC(O)=O)C(C2=C(OC)C=C(C3=CC=C(O)C=C3)C(OC)=C2O)=C1

Molecular Formula

C20H18O8

Molecular Weight

386.35

References & Citations

[1]Sascha Sauer, et al. Foam cell specific Liver X Receptor (LXR) alpha agonist, SIRT1 inhibitors as well as p300 inhibitors as pharmaceutically active agentsPatent. EP2759295

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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