SIRT1-IN-6

SIRT1-IN-6 (Compound NP1) is a SIRT1 inhibitor (IC50: 9.7 μM) . SIRT1-IN-6 increases p53 acetylation. SIRT1-IN-6 can be used for research of prophylaxis and neurodegenerative diseases or cancer[1].

Product Specifications

CAS Number

[1174387-32-6]

UNSPSC

12352005

Target

MDM-2/p53; Sirtuin

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Smiles

O=C1OC(CC(O)=O)C(C2=C(OC)C=C(C3=CC=C(O)C=C3)C(OC)=C2O)=C1

Molecular Formula

C20H18O8

Molecular Weight

386.35

References & Citations

[1]Sascha Sauer, et al. Foam cell specific Liver X Receptor (LXR) alpha agonist, SIRT1 inhibitors as well as p300 inhibitors as pharmaceutically active agentsPatent. EP2759295