Osimertinib dimer
Osimertinib dimer is a dimer of Osimertinib. Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer[1][2].
Product Specifications
CAS Number
2564638-97-5
UNSPSC
12352005
Target
Drug Derivative
Related Pathways
Others
Field of Research
Cancer
Smiles
O=C(NC1=CC(NC2=NC(C3=CN(C)C4=C3C=CC=C4)=CC=N2)=C(C=C1N(CC[N+](C)(CCC(NC5=CC(NC6=NC(C7=CN(C)C8=C7C=CC=C8)=CC=N6)=C(C=C5N(CCN(C)C)C)OC)=O)C)C)OC)C=C
Molecular Formula
C56H67N14O4+
Molecular Weight
1000.22
References & Citations
[1]Yuan BZ, et al. Oxitinib dimer, preparation method and application thereof. CN112028880A. |[2]Cross DA, et al. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 2014 Sep;4 (9) :1046-61.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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