Keap1-IN-2
Keap1-IN-2 (Compound 164) is a KEAP1 inhibitor (IC50: 2 nM) . Keap1-IN-2 indirectly activates Nrf2 by inhibiting KEAP1, thereby enhancing the antioxidant capacity of cells. Keap1-IN-2 promotes the accumulation and nuclear translocation of Nrf2 by blocking KEAP1-mediated Nrf2 degradation. Keap1-IN-2 can be used to study diseases associated with oxidative stress, such as inflammatory bowel disease, Crohn's disease, and immune diseases such as ulcerative colitis[1].
Product Specifications
CAS Number
[3066895-41-5]
UNSPSC
12352005
Target
Keap1-Nrf2
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CC(N1[C@H](C2=CC(Cl)=NC(C3=NC=NC(C(NC)=O)=C3)=C2)CN(C[C@H]1C)C(C=C)=O)=O
Molecular Formula
C21H23ClN6O3
Molecular Weight
442.90
References & Citations
[1]Karl BEDKE, et al. Keap1 inhibitors and uses thereof. WO2024259171A2. WO. 2024-06-13
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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