Modzatinib
Modzatinib (ITK kinase-IN-1) (compound I) is an inhibitor targeting ITK kinase (IC50=8 nM, Jurkat cells) and can be used to study inflammatory diseases. Modzatinib has an IC50 of 23 nM for JAK3 in hPBMC cells (based on IL-2/pSTAT5 levels), wihout inhibitory effect against JAK2[1].
Product Specifications
CAS Number
2411407-25-3
Product Name Alternative
ITK kinase-IN-1
UNSPSC
12352005
Target
Itk; JAK
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
FC(F)(C1)[C@H]1C2=CNC3=NC=NC(N[C@H]4CN([C@H](CC4)C)C(C=C)=O)=C23
Molecular Formula
C18H21F2N5O
Molecular Weight
361.39
References & Citations
[1]FRATTINI, et al.Pyrrolopyrimidine compositions in combination with ITK kinase inhibitors for treating inflammatory conditions. World Intellectual Property Organization, WO2024102778 A1. 2024-05-16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK3
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
GTR15316171 1 Vial
Lentiviral human SEC31B shRNA (UAS) - Lentiviral human SEC31B shRNA (UAS, iRFP) plasmid
Sign In for Pricing
View Details 
040751-HRP 200 µL
RAB25, ID (RAB25, CATX8, Ras-related protein Rab-25, CATX-8) (Azide free) (HRP)
Sign In for Pricing
View Details K6294602 1.0 µg DNA
Cntnap5a sgRNA CRISPR Lentivector (Rat) (Target 1)
Sign In for Pricing
View Details 
F6998-25A-FITC 200 µL
FRK, NT (Tyrosine-protein Kinase FRK, Nuclear Tyrosine Protein Kinase RAK, FYN-related Kinase, Protein-tyrosine Kinase 5, PTK5, RAK) (FITC) discontinued
Sign In for Pricing
View Details