Modzatinib
Modzatinib (ITK kinase-IN-1) (compound I) is an inhibitor targeting ITK kinase (IC50=8 nM, Jurkat cells) and can be used to study inflammatory diseases. Modzatinib has an IC50 of 23 nM for JAK3 in hPBMC cells (based on IL-2/pSTAT5 levels), wihout inhibitory effect against JAK2[1].
Product Specifications
CAS Number
[2411407-25-3]
Product Name Alternative
ITK kinase-IN-1
UNSPSC
12352005
Target
Itk; JAK
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
FC(F)(C1)[C@H]1C2=CNC3=NC=NC(N[C@H]4CN([C@H](CC4)C)C(C=C)=O)=C23
Molecular Formula
C18H21F2N5O
Molecular Weight
361.39
References & Citations
[1]FRATTINI, et al.Pyrrolopyrimidine compositions in combination with ITK kinase inhibitors for treating inflammatory conditions. World Intellectual Property Organization, WO2024102778 A1. 2024-05-16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK3
Available Sizes
Curated Selection
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