Antitumor agent-203

Antitumor agent-203 (compound 26) is a derivative of Exatecan (DX-8951) (HY-13631) and can be used to prepare antibody-drug conjugates (ADCs), as the ADC Cytotoxin[1].

Product Specifications

CAS Number

[2577204-44-3]

UNSPSC

12352005

Target

ADC Payload; Topoisomerase

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.07

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@H](O)C(N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62)=O

Molecular Formula

C27H26FN3O6

Molecular Weight

507.51

References & Citations

[1]Zhu Yi, et al. Preparation of exatecan derivatives and exatecan antibody conjugates useful for the treatment of cancer. China, CN111689980 A. 2020-09-22.