ERK2-IN-6
ERK2-IN-6 (Compound 20) is a highly selective ERK1/2 inhibitor with an IC50 value of 7.9 nM for ERK2. ERK2-IN-6 inhibits the proliferation of BRAFV600E mutant cells (IC50=250 nM in A375 cells) . ERK2-IN-6 is promising for research of solid tumors, such as BRAF-mutated melanoma[1].
Product Specifications
CAS Number
2095713-33-8
UNSPSC
12352005
Target
ERK
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C1C2=C(CN1CC(NC(C)(C)C3=CC=CC=C3)=O)C=CC(C4=NC(NC5CCOCC5)=NC=C4Cl)=C2
Molecular Formula
C28H30ClN5O3
Molecular Weight
520.02
References & Citations
[1]Heightman TD, et al. Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J Med Chem. 2018 Jun 14;61 (11) :4978-4992.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK1; ERK2
Frequently Asked Questions
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