GSK-3β inhibitor 27
GSK-3β inhibitor 27 (Compound 1c) is a reversible and competitive GSK-3β inhibitor with an IC50 value of 2.2 μM. GSK-3β inhibitor 27 inhibits tau hyperphosphorylation, reduces Aβ protein aggregation and possesses metal chelation and neuroprotective potential. GSK-3β inhibitor 27 is promising for research of neurodegenerative diseases (such as Alzheimer’s disease) [1].
Product Specifications
UNSPSC
12352005
Target
Amyloid-β; GSK-3
Related Pathways
Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Neurological Disease
Smiles
O=C(N(CC1=CC=C(Cl)C=C1)C)/C=C\C(NC2=NNC(C)=C2)=O
Molecular Formula
C16H17ClN4O2
Molecular Weight
332.78
References & Citations
[1]Orioli R, et al. Exploiting acylaminopyrazole scaffold for polypharmacology approach in Alzheimer's disease. Eur J Med Chem. 2025 May 25;295:117799.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β
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