HIV Capsid-IN-2

HIV Capsid-IN-2 (Compound IC-2b4) is a potent HIV-1 capsid protein (CA) inhibitor. HIV Capsid-IN-2 shows inhibitory effects against both HIV-1 (EC50=0.08 μM) and HIV-2. HIV Capsid-IN-2 exerts inhibitory effects during both early and late stages of infection by directly and stably binding to HIV-1 CA[1].

Product Specifications

UNSPSC

12352005

Target

HIV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(N(C1=CC=C(OC)C=C1)C)[C@@H](NC(CN2C(CN(S(=O)(C3=CC=C(N)C=C3F)=O)CC2)=O)=O)CC4=CC(F)=CC(F)=C4

Molecular Formula

C29H30F3N5O6S

Molecular Weight

633.64

References & Citations

[1]Shi D, et al. Design, synthesis and structure-activity relationships of novel HIV capsid inhibitors with potent antiviral activities. Eur J Med Chem. 2025 May 22;295:117784.