FGFR-IN-21
FGFR-IN-21 (Compound FP1) is a selective covalent FGFR4 inhibitor with an IC50 value of 70 nM. FGFR-IN-21 is promising for research of FGFR signaling pathways in cancers[1].
Product Specifications
UNSPSC
12352005
Target
FGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
C=CC(NC1=CC=C(CN(C2=NC(NC3=CC=C(N4CCN(CCC#C)CC4)C=C3)=NC=C2CN5C6=CC(OC)=CC(OC)=C6)C5=O)C=C1)=O
Molecular Formula
C38H40N8O4
Molecular Weight
672.78
References & Citations
[1]Zhu D, et al. Design, synthesis and biological evaluation of the activity-based probes for FGFR covalent inhibitor. Eur J Med Chem. 2025 May 22;295:117795.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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