ATX-IN-2
ATX-IN-2 (Compound 25) is an orally active and potent ATX inhibitor with an IC50 value of 3.27 nM. ATX-IN-2 reduces lysophosphatidic acid (LPA) secretion. ATX-IN-2 is promising for research of ATX-mediated diseases, such as inflammation, pulmonary fibrosis[1].
Product Specifications
CAS Number
3076224-81-9
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(N1CC2(COC2)C1)C3(CC3)N4CCN(C(S5)=NN6C5=NC(CC)=C6N(C([2H])([2H])[2H])C7=NC(C8=CC=C(F)C=C8)=C(C#N)S7)CC4
Molecular Formula
C30H29D3FN9O2S2
Molecular Weight
636.78
References & Citations
[1]Wang H, et al. Successive structural optimization of Ziritaxestat culminates in the discovery of orally bioavailable and in vivo potent imidazothiadiazole derivative for treating ATX-driven diseases. Eur J Med Chem. 2025 May 21;295:117769.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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