HDAC6-IN-60

HDAC6-IN-60 (Compound 12) is an orally active and selective HDAC6 inhibitor. HDAC6-IN-60 exerts effects on tumor cell proliferation by inhibiting the enzymatic activity of HDAC6 and regulating pathways related to protein homeostasis. HDAC6-IN-60 is promising for research of HDAC6- related cancers[1].

Product Specifications

CAS Number

[3095060-37-7]

UNSPSC

12352005

Target

HDAC

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

O=C(NNCC)C(C=C1)=CC=C1CN2C3=CC=CC=C3C(C4=CC=CO4)=N2

Molecular Formula

C21H20N4O2

Molecular Weight

360.41

References & Citations

[1]Ali KH, et al. Design, synthesis, and biological evaluation of indazole-based histone deacetylase 6 inhibitors. Eur J Med Chem. 2025 May 22;295:117785.