Neuroprotective agent 11
Neuroprotective agent 11 (Compound 1a) is an orally active polyphenol compound with significant protective effects against cerebral ischemia. The main activities of Neuroprotective agent 11 include inhibiting neuronal inflammation and apoptosis, reducing cerebral infarction volume, and improving behavioral symptoms of cerebral ischemic mice. Neuroprotective agent 11 exerts its regulatory mechanism by downregulating the expression of inflammatory factors (iNOS、COX-2) and apoptotic proteins (cleaved-Caspase3, p53) . Neuroprotective agent 11 can be used in the study of cerebral ischemia-related diseases (such as ischemic stroke) [1].
Product Specifications
CAS Number
[3081915-81-0]
UNSPSC
12352005
Target
Caspase; COX; MDM-2/p53; NO Synthase
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Neurological Disease
Smiles
CCC1=C2C([C@@H](C3=C(O)C=C(O)C4=C3O[C@H](C5=CC=C(O)C(O)=C5)[C@@H](O)C4)[C@H](O)[C@@H](C6=CC=C(O)C(O)=C6)O2)=C(O)C=C1O
Molecular Formula
C32H30O12
Molecular Weight
606.57
References & Citations
[1]Chang Jun, et al. Polyphenol compounds, preparation method therefor and use thereof. WO2025082357A1. China, CN2024124990. 2025-04-24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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