Muscarinic M4 modulator-1
Muscarinic M4 modulator-1 is a Muscarinic M4 receptor positive allosteric modulator. Muscarinic M4 modulator-1 activates the muscarinic M4 receptor with allosteric potency EC50 s of 14 and 3 Nm in CHO-K1 cells and HEK293 cells. Muscarinic M4 modulator-1 has an antipsychotic-like activity, promising for psychiatric and/or neurological disorders research[1].
Product Specifications
CAS Number
[3082186-91-9]
UNSPSC
12352005
Target
MAChR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
CC1=CC2=NC(C)=NN2C3=C1CN(C(CC4CN(C5=CC(C(F)F)=NC=C5)C4)=O)C3
Molecular Formula
C21H22F2N6O
Molecular Weight
412.44
References & Citations
[1]Ramakrishna Nirogi, et al. Heteroaromatic compounds as muscarinic m4 receptor positive allosteric modulators (m4 pams) . WO2025083630A1. 2025-04-24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR4
Curated Selection
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