RCD405
RCD405 is a bronchodilator. RCD405 exerts relaxant effects by acting directly on human airway smooth muscle (hASM) with an EC50 value of 12 μM for histamine-induced contractions and 45.71 μM for carbachol-induced contractions. RCD405 inhibits cholinergic and histaminergic tone and reduces electrically stimulated (EFS) -induced contractions. RCD405 is promising for research of asthma and chronic obstructive pulmonary disease (COPD) [1].
Product Specifications
CAS Number
2408134-22-3
UNSPSC
12352101
Target
Others
Related Pathways
Others
Field of Research
Inflammation/Immunology
Smiles
OC1=C(O)C(Cl)=C(CCN(C(CSC2=CN=C(C(F)(F)F)C=C2)=O)C3)C3=C1Cl
Molecular Formula
C17H13Cl2F3N2O3S
Molecular Weight
453.26
References & Citations
[1]Rogliani P, et al. Characterisation of the novel quinoline RCD405: Relaxant effects on cholinergic and histaminergic tone in human bronchi and small airways. Br J Pharmacol. 2025 May 19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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