AKT-IN-28

AKT-IN-28 is an Akt allosteric inhibitor, a derivative of Shikonin (HY-N0822) . AKT-IN-28 effectively binds to the allosteric site of Akt through hydrophobic and hydrogen interactions with Kd of 2.07 μM. AKT-IN-28 significantly inhibits Akt activity, induces cell apoptosis, arrests cell cycle in G2/M phase, and suppresses proliferation, migration and metabolism of KRAS mutant colorectal cancer cells[1].

Product Specifications

UNSPSC

12352005

Target

Akt; Apoptosis; Caspase; PARP; β-catenin

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

OC1=CC=C(O)C2=C1C(C=C(C(OC(CC3=CC=C(NC(COC4=CC=C(F)C=C4)=O)C=C3)=O)C/C=C(C)\C)C2=O)=O

Molecular Formula

C32H28FNO8

Molecular Weight

573.57

References & Citations

[1]Ma Y, et al. Novel Phenoxyacetic Acid (4-Aminophenoacetic Acid) Shikonin Ester Kills KRAS Mutant Colon Cancer Cells via Targeting the Akt Allosteric Site. Chem Biol Drug Des. 2025 May; 105 (5) :e70125.