AKT-IN-28
AKT-IN-28 is an Akt allosteric inhibitor, a derivative of Shikonin. AKT-IN-28 effectively binds to the allosteric site of Akt through hydrophobic and hydrogen interactions with Kd of 2.07 μM. AKT-IN-28 significantly inhibits Akt activity, induces cell apoptosis, arrests cell cycle in G2/M phase, and suppresses proliferation, migration and metabolism of KRAS mutant colorectal cancer cells[1].
Product Specifications
UNSPSC
12352005
Target
Akt; Apoptosis; Caspase; PARP; β-catenin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
OC1=CC=C(O)C2=C1C(C=C(C(OC(CC3=CC=C(NC(COC4=CC=C(F)C=C4)=O)C=C3)=O)C/C=C(C)\C)C2=O)=O
Molecular Formula
C32H28FNO8
Molecular Weight
573.57
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt; Caspase 3; PARP
Frequently Asked Questions
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