HSD17B13-IN-105
HSD17B13-IN-105 (Compound EX.87) is a selective 17β-hydroxysteroid dehydrogenase 13 (17BHSD13) inhibitor with an IC50 value of 0.036 μM, showing high selectivity over 17BHSD4 (with an IC50 value of 31.5 μM) . HSD17B13-IN-105 is promising for research of liver diseases such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) [1][2].
Product Specifications
CAS Number
[3012624-88-0]
UNSPSC
12352005
Target
17β-HSD
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=C(N1C[C@@H](C)O[C@@H](C)C1)C2=NOC(C3=CC(F)=C(F)C(O)=C3F)=N2
Molecular Formula
C15H14F3N3O4
Molecular Weight
357.28
References & Citations
[1]Christopher Sebastian Gerald KNEE. Crystalline form of an amido heteroaromatic compound. WO2025104564A1. 2025-05-22.|[2]Daniel Tor Pettersen, et al. Amido heteroaromatic compounds useful in the treatment of liver diseases. WO2023222850A1. 2023-11-23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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