HSV-1/HSV-2-IN-3
HSV-1/HSV-2-IN-3 inhibits the herpes-simplex-virus (HSV) helicase-primase complex, blocking the coordinated DNA-unwinding and primer-synthesis steps required for viral genome replication. HSV-1/HSV-2-IN-3 exhibits an EC50 of 7.0 nM against HSV-2 in a gD-immunofluorescence cell assay containing 2 % FBS and 57.5 nM when 10 % human serum is present. HSV-1/HSV-2-IN-3 achieves an EC50 of 1.1 nM in a qPCR replication assay. HSV-1/HSV-2-IN-3 shows strong selectivity over human carbonic-anhydrase off-targets (IC50 ≈ 2.9 µM for hCA II and > 35 µM for hCA I) . HSV-1/HSV-2-IN-3 can be studied in anti-HSV research[1].
Product Specifications
CAS Number
3016396-78-1
UNSPSC
12352005
Target
HSV
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=C(N1[C@H](C)CC2=C1C=C(S(=O)(N)=O)C(F)=C2)[C@@H](C3)CC(C3=C4)=CC=C4C5=NC=CC=C5
Molecular Formula
C24H22FN3O3S
Molecular Weight
451.51
References & Citations
[1]Aesop Cho, et al., WO2023225162 Antiviral indolinyl compounds and uses thereof cross reference to related applications.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Tripartite motif containing protein 77 (TRIM77) Human Gene Knockout Kit (CRISPR)
