HSV-1/HSV-2-IN-3
HSV-1/HSV-2-IN-3 inhibits the herpes-simplex-virus (HSV) helicase-primase complex, blocking the coordinated DNA-unwinding and primer-synthesis steps required for viral genome replication. HSV-1/HSV-2-IN-3 exhibits an EC50 of 7.0 nM against HSV-2 in a gD-immunofluorescence cell assay containing 2 % FBS and 57.5 nM when 10 % human serum is present. HSV-1/HSV-2-IN-3 achieves an EC50 of 1.1 nM in a qPCR replication assay. HSV-1/HSV-2-IN-3 shows strong selectivity over human carbonic-anhydrase off-targets (IC50 ≈ 2.9 µM for hCA II and > 35 µM for hCA I) . HSV-1/HSV-2-IN-3 can be studied in anti-HSV research[1].
Product Specifications
CAS Number
[3016396-78-1]
UNSPSC
12352005
Target
HSV
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=C(N1[C@H](C)CC2=C1C=C(S(=O)(N)=O)C(F)=C2)[C@@H](C3)CC(C3=C4)=CC=C4C5=NC=CC=C5
Molecular Formula
C24H22FN3O3S
Molecular Weight
451.51
References & Citations
[1]Aesop Cho, et al., WO2023225162 Antiviral indolinyl compounds and uses thereof cross reference to related applications.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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