CRBN ligand-186

CRBN ligand-186 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC[1].

Product Specifications

CAS Number

[3084710-09-5]

UNSPSC

12352005

Target

Ligands for E3 Ligase

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

N#CC(C(NS(=O)(N(CC)C)=O)=CC=C1F)=C1OC(C=C2C3=O)=CC=C2N=CN3[C@@H]4COC5(C4)CCN(CC5)C(CN6CCC(CC6)C7=CC=C(C=C7OS(=O)(F)=O)C8CCC(NC8=O)=O)=O

Molecular Formula

C44H48F2N8O11S2

Molecular Weight

967.03

References & Citations

[1]Kimberly Muno HILBY, et al. Covalent cereblon ligands. WO2025096856A1. 2025-05-08.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

NBP3-08302PE 100 µL

Mouse Monoclonal Homez Antibody (PCRP-HOMEZ-1A5) [PE]

Ask

View Details

AP9C497-01 1 mg

Recombinant Bovine Angiopoietin-Related Protein 4 (ANGPTL4), N-His

Ask

View Details

AP9C497-02 10 µg

Recombinant Bovine Angiopoietin-Related Protein 4 (ANGPTL4), N-His

Ask

View Details

AP9C497-03 200 µg

Recombinant Bovine Angiopoietin-Related Protein 4 (ANGPTL4), N-His

Ask

View Details

AP9C497-04 5 mg

Recombinant Bovine Angiopoietin-Related Protein 4 (ANGPTL4), N-His

Ask

View Details

AP9C497-05 50 µg

Recombinant Bovine Angiopoietin-Related Protein 4 (ANGPTL4), N-His

Ask

View Details