PS21M
PS21M is a negative control of CPS-021 (HY-174247) . PS21M cannot effectively degrade PAK4 in MDA-MB-231 cells. (Pink: Target Protein Ligand (HY-174822) ; Black: Linker; Blue: E3 Ligase Ligand (HY-W586822) ) [1].
Product Specifications
UNSPSC
12352005
Target
PAK; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; PROTAC
Field of Research
Cancer
Smiles
O=C(C1=CN(C2=NC(N)=NC=C2)C3=C1C=CC(C#CC4(O)CCCCC4)=C3)N5CCN(CC5)CCCCCCCC(N6CCN(CCNC7=CC=CC(C(N8C9CCC(N(C)C9=O)=O)=O)=C7C8=O)CC6)=O
Molecular Formula
C53H65N11O7
Molecular Weight
968.15
References & Citations
[1]Wang H, et al. Design, Synthesis, and Biological Evaluation of Selective PAK4 Degrader for the Treatment of Lung Tumor Metastasis. J Med Chem. 2025 Jun 12;68 (11) :11231-11269.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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