KRASG12D-IN-5
KRASG12D-IN-5 (Compound 241) is an orally active KRAS (G12D) inhibitor with an IC50 of 11 nM. KRASG12D-IN-5 has potent anticancer activity with no significant cytotoxicity against BxPC-3 (WT), KRAS mutation AsPC-1 (G12D) and MIAPaCa-2 cells (G12C) with CC50s of 10.37, 0.76 and 0.3 μM, respectively. KRASG12D-IN-5 can be used for cancer research, such as lung, pancreatic and colorectal cancer[1].
Product Specifications
CAS Number
[2933935-13-6]
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
OC1=CC2=C(C(C#C)=C(C=C2)F)C(C3=C(F)C4=C(C=N3)C(N5[C@H](C(F)F)[C@H]6CC[C@](C5)([H])N6)=NC(OC[C@]78C[C@@H](F)CN7CCC8)=N4)=C1
Molecular Formula
C34H31F5N6O2
Molecular Weight
650.64
References & Citations
[1]Volodymyr KYSIL, et al. Kras (g12d) inhibitors. WO2025085580A1. 2025-04-24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
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