Thalidomide-OCH2-amide-PEG2-C2-Boc
Thalidomide-OCH2-amide-PEG2-C2-Boc is an E3 ligase ligand-linker conjugate containing a cereblon (CRBN) ligand for E3 ubiquitin ligase and a linker. Thalidomide-OCH2-amide-PEG2-C2-Boc can be used to synthesize PROTAC SARS-CoV-2 Degrader-1 (HY-174233) [1].
Product Specifications
CAS Number
[2827750-18-3]
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Infection
Smiles
O=C(COC1=C2C(C(N(C3CCC(NC3=O)=O)C2=O)=O)=CC=C1)NCCOCCOCCC(OC(C)(C)C)=O
Molecular Formula
C26H33N3O10
Molecular Weight
547.55
References & Citations
[1]Veeck C, et al. Discovery of an Antiviral PROTAC Targeting the SARS-CoV-2 Main Protease Using an Allosteric Warhead[J]. bioRxiv, 2025: 2025.05. 03.652023.Discovery of an Antiviral PROTAC Targeting the SARS-CoV-2 Main Protease Using an Allosteric Warhead[J]. bioRxiv, 2025: 2025.05. 03.652023.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-174235/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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