Thalidomide-OCH2-amide-PEG2-C2-Boc

Thalidomide-OCH2-amide-PEG2-C2-Boc is an E3 ligase ligand-linker conjugate containing a cereblon (CRBN) ligand for E3 ubiquitin ligase and a linker. Thalidomide-OCH2-amide-PEG2-C2-Boc can be used to synthesize PROTAC SARS-CoV-2 Degrader-1 (HY-174233) [1].

Product Specifications

CAS Number

[2827750-18-3]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Field of Research

Infection

Smiles

O=C(COC1=C2C(C(N(C3CCC(NC3=O)=O)C2=O)=O)=CC=C1)NCCOCCOCCC(OC(C)(C)C)=O

Molecular Formula

C26H33N3O10

Molecular Weight

547.55

References & Citations

[1]Veeck C, et al. Discovery of an Antiviral PROTAC Targeting the SARS-CoV-2 Main Protease Using an Allosteric Warhead[J]. bioRxiv, 2025: 2025.05. 03.652023.Discovery of an Antiviral PROTAC Targeting the SARS-CoV-2 Main Protease Using an Allosteric Warhead[J]. bioRxiv, 2025: 2025.05. 03.652023.