SM311
SM311 (Compound 10), a chemical probe, is a potent selective irreversible LIMK1 inhibitor (EC50=0.045 μM, >30-fold selective over LIMK2) . SM311 blocks cofilin phosphorylation and actin cytoskeleton regulation. SM311 is promising for research of neurodegenerative diseases like Fragile X syndrome (FXS) and Alzheimer’s disease, as well as tumor invasion[1].
Product Specifications
UNSPSC
12352100
Target
LIM Kinase (LIMK)
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Smiles
FC(F)C1=NN(C2=CC=C(NC(C=C)=O)C=C2)C(C3=CN=C(NC(C(C)C)=O)S3)=C1
Molecular Formula
C20H19F2N5O2S
Molecular Weight
431.46
References & Citations
[1]Mandel S, et al. Covalent targeting leads to the development of LIMK1 isoform-selective inhibitors[J]. bioRxiv, 2025: 2025.04. 17.649341.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-174229/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LIMK1; LIMK2
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