Topoisomerase inhibitor 6
Topoisomerase inhibitor 6 (Compound REDX05931) is a dual irreversible inhibitor of DNA gyrase and topoisomerase IV (MIC=0.06 μg/mL against fluoroquinolone-resistant S. aureus) . Topoisomerase inhibitor 6 blocks DNA strand break-reunion, inducing lethal DNA damage. Topoisomerase inhibitor 6 is promising for research of Gram-positive bacterial infections (e.g., S. aureus, S. pneumoniae) [1].
Product Specifications
CAS Number
[2987726-03-2]
UNSPSC
12352005
Target
Bacterial; Topoisomerase
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Infection
Smiles
C[C@H](N)[C@H]1CN(C2=C(Cl)C(N(C3CC3)C(C4=C5OC(C)=N4)=O)=C5C=C2F)CC1
Molecular Formula
C20H22ClFN4O2
Molecular Weight
404.87
References & Citations
[1]Kirk R, et al. Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 2. RSC Med Chem. 2020 Sep 18;11 (12) :1379-1385.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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